Furthermore clinical pharmacologists consider anti epi leptic drugs as model drugs in pharmacokinetics and pharmocodynamics since reliable methods are available for their determination and their effects and side effects can be defined the methods of estimating of drugs in body fluids provide a tool that enables us to throw light on many obscure relationships in pharmaceutical treatment . Pht michaelis menton kinetic parameters have been reported to clinical pharmacology of antiepileptic drugs 181 be unchanged in aged patients compared with controls in the literature but a study in patients over the age range 21 to 78 found a 15 decrease in maximal rate of pht biotransformation vmax560 thus patients would tend to develop higher pht levels for the same doses than younger patients as steady state concentration varies inversely with vmax. Intravenous iv administration of antiepileptic drugs aeds produces the most rapid onset of action as it is delivered directly into the bloodstream and immediately produces maximal plasma concentration c 0 c maxin addition to its therapeutic value iv administration is essential in investigating the pharmacokinetics pk or clinical pharmacology of drugs as it bypasses absorption . Clinical pharmacology and therapeutic use of the new antiepileptic drugs perucca e1 author information 1clinical pharmacology unit department of internal medicine and therapeutics university of pavia pavia italy peruccaunipvit erratum in fundam clin pharmacol 2002 jun163249 although older generation antiepileptic drugs aeds such as carbamazepine phenytoin and valproic . This article illustrates basic principles of clinical pharmacology presented in article 1 with specific examples from the treatment of seizure disorders the discussion includes protein binding the role of a major carbamazepine metabolite alterations in pharmacology of aeds in the elderly and aed withdrawal the last topic in particular is a good example of the interaction of
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